12/10/2023 0 Comments Vitamins for sperm production![]() About 25% of infertile men were demonstrated to have a high ROS level in their semen. An excessive amount of ROS causes increase lipid peroxidation and DNA damage in the sperm cell, ultimately disruptive effect on sperm function leads to infertility. įree radicals or ROS are highly reactive oxygen-derived molecules that are produced by sperm cells in small amount and play an essential role in sperm capacitation, sperm maturation, and cellular signaling pathway. Previous efforts have highlighted a significant contribution of oxidative stress, caused by too high amounts of oxidants or too low levels of antioxidants, in idiopathic infertility. ![]() In most of the cases, the main cause of male factor infertility at the molecular level remains unknown. Vitamin E, vitamin C, zinc, folic acid, coenzyme Q10, selenium, l-carnitines, N-acetyl cysteine, and lycopene are the most commonly prescribed. Several studies represented a significant positive impact of antioxidant supplements on semen characteristics, pregnancy, and success rates for assisted reproductive technology (ART). Live birth rates between the groups that had oral administration of vitamin E supplement were compared to those who took the placebo and found no significant difference between them. We compared the differences in sperm concentration, morphology, and motility as well as pregnancy rate. ![]() This study is aimed at considering the influence of fixed-dose 400 IU synthetic vitamin E on semen parameters of men who have infertility. The purpose of this project was to study if consumption of 400 IU synthetic vitamin E ( α-tocopherol) daily for eight weeks can affect semen parameters or pregnancy outcomes in couples with male factor infertility. However, some efforts have explored paradoxical results. Previous researchers have stated that the male supplementation by antioxidants such as vitamins E and C before intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) decreased the level of DNA damage and therefore enhanced pregnancy success rates. Many studies have revealed a strong positive relevance between antioxidant consumption and improved male infertility. Īntioxidants including vitamin E, superoxide dismutase, vitamin C, thioredoxin, and glutathione can neutralize free radical activity to keep sperm from produced ROS and subsequently improve male fertility. An extreme level of ROS can damage sperm DNA through the stimulation of sperm caspases and endonucleases. Lipid peroxidation mechanism seriously impresses on membrane function and subsequently decreases sperm quality. Sperm plasma membrane consists of a large amount of polyunsaturated fatty acids that are assailable by ROS. Previous researchers showed that ROS and oxidative stress reduce male fertility. The environmental factors such as air pollution, electromagnetic radiation, and poor nutrition cause to amplify reactive oxygen species (ROS) and subsequent oxidative stress. Although several nutrient supplementation products are promised to improve semen parameters, there are a few available evidence-based data regarding nutrient effects on the treatment of male infertility. Some factors such as infection, environmental, and genetic factors are associated with semen quality however, the implicated etiology is poorly understood. Evaluation of semen parameters and quality is the first laboratory step for assessing male fertility problems. ĭecreased function and quality of sperm lead to decreased male fertilization potential. In around half of the infertile couples, a male factor is the only identifiable cause. ![]() Infertility is a significant clinical problem, affecting about 15% of all couples at reproductive age. ![]()
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